The Tiber is a corner of Tuscany is not very well known but of great interest both from a naturalistic point of view and from the historical, artistic and religious. The lucky visitor to this valley is located amidst an incredibly diverse, unspoiled and spectacular in some places dotted here and there with hermitages, old farmhouses to witness the rural life, churches and castles. In a natural amphitheater surrounded by rolling hills, open the plain crossed by the Tiber River for about 40 km and where more than observe, we breathe art, history and culture. The hills, the characteristics halfway between Tuscany and Umbria, are the scenery around the ancient villages which stand as Sansepolcro and Anghiari famous one for the painter Piero della Francesca, who immortalized the Tiber valley landscape, and the other for its ancient medieval architecture and the framework of the “Battle” painting by Leonardo da Vinci. Recall also countries such as Pieve Santo Stefano, with its internationally important archive diary, Monterchi and his Madonna del Parto one of the most beautiful frescoes by Piero della Francesca, Caprese Michelangelo, who gave birth to Michelangelo Buonarroti and Sestino known for its training geological detail.